Continuous vecuronium infusion for prolonged muscle relaxation in children

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Continuous vecuronium infusion for prolonged muscle relaxation in children.

Facilitation of mechanical ventilation of the lungs using an infusion of vecuronium in 11 infants and children and four neonates in an intensive care unit is described. A loading dose of vecuronium of 0.1 mg.kg-1 was followed by an infusion at an initial rate of 0.1 mg.kg-1.hr-1. The infusion rate was adjusted to maintain a neuromuscular block of approximately 90% as assessed by the presence of...

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Comparison between the continuous infusion of vecuronium and the intermittent administration of pancuronium and vecuronium.

The neuromuscular blocking effects of repeated bolus injections of pancuronium, or vecuronium, and of the continuous infusion of vecuronium have been compared in 36 patients by means of evoked twitch tension. Groups I and II received a loading dose (0.075 mg kg-1) of pancuronium or vecuronium, respectively, followed by 0.015-mg kg-1 maintenance doses when twitch tension had recovered to 25% of ...

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Phase I trial of homoharringtonine administered by prolonged continuous infusion.

Cephalotaxine alkaloids have been extensively used in the Peoples Republic of China for treatment of acute leukemias and solid tumors (Yu-hua, L., Shu-fen, G., Fu-ying, Z., Shu-zhi, X., and Hui-lin, Z. Chin. Med. J., 96: 303-305, 1983). Several Phase I trials of homoharringtonine have been completed in the United States using either bolus administration or continuous infusion over a 5-day perio...

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Prolonged Infusion of Dexmedetomidine in Critically-ill Children.

OBJECTIVE To describe main indications, doses, length of infusion and side effects related to dexmedetomidine infusion. METHODS Observational and retrospective study evaluating dexmedetomidine use in pediatric intensive care unit. RESULTS 77 children received dexmedetomidine infusion longer than 6 hours for mechanical ventilation weaning (32.5%), post- neurosurgery and post-upper airway sur...

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Prolonged infusion of suxamethonium in infants and children.

The neuromuscular blockade produced by a prolonged (greater than 90 min) continuous infusion of suxamethonium and measured with train-of-four stimulation was studied in 20 infants and 20 children during nitrous oxide and halothane in oxygen anaesthesia. The results were compared with a previous study in adults. Suxamethonium requirement was increased in infants and children. Mean peak infusion ...

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ژورنال

عنوان ژورنال: Canadian Journal of Anaesthesia

سال: 1991

ISSN: 0832-610X,1496-8975

DOI: 10.1007/bf03008139